I saw a tip recently in Quilting Arts Magazine, the Oct/Nov 2011 issue (yes, I'm a little behind in my reading) about using binder clips to hold the binding on while quilting, instead of using pins.
The next day I was sewing binding to a queen-sized bed quilt and thought I'd try it out and it worked like a charm! I'm not sure if it saved me any time but it was a lot less cumbersome than using pins and I didn't have to worry about the pins catching on the quilt or each other when I moved it around on the table. And there were also no pins to stick me while I was sewing.
It seems obvious to me now, after all, they are called "binder" clips.